Increased thalamic glutamate/glutamine levels in migraineurs

Abstract Background Increased cortical excitability has been hypothesized to play a critical role in various neurological disorders, such as restless legs syndrome, epilepsy and migraine.Particularly for migraine, local hyperexcitability has been reported.Levels of regional excitatory and inhibitory neurotransmitters are related to cortical excitab

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Deregulation of the imprinted DLK1-DIO3 locus ncRNAs is associated with replicative senescence of human adipose-derived stem cells.

BACKGROUND:Human adult adipose-derived stem cells (hADSCs) have become the most promising cell source for regenerative medicine.However the prolonged ex vivo expansion periods required to obtain BOOTS the necessary therapeutic dose promotes progressive senescence, with the concomitant reduction of their therapeutic potential.AIM AND SCOPE:A better

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